Clinical Insights
Evidence-based writing on hormones, metabolic health, longevity, cardiovascular risk and body composition — from Dr. Luke Sorrell, MD FACP.
Trouble falling asleep and waking in the middle of the night are two different problems with two different explanations. The second one is usually a signal being sent from somewhere else in the body.
Read ArticleTwo measurements outperform most of what appears on a standard panel at predicting all-cause mortality. Neither requires a blood draw, and almost no one is ever told their number.
Read ArticleIt can begin in your late thirties and run for the better part of a decade. Most women are told their labs are normal and sent home — because the test they were given cannot answer the question they came in with.
Read ArticleAbout one in five people carry an inherited particle that raises the risk of heart attack and aortic valve disease. It is not on the standard panel — and a normal cholesterol result does not rule it out.
Read ArticleMost people's supplement shelf is the accumulated residue of a decade of good intentions and podcast episodes. Almost none of it was ever chosen for them, specifically, on the basis of anything measured.
Read ArticleGLP-1 medications are the most effective weight-loss tools we have ever had. Used without a plan, they also take a meaningful share of the one tissue you can least afford to lose.
Read ArticleTwo people drink the same two cups a day. In one, it's protective. In the other, it tracks with a measurably higher risk of a heart attack. The difference is a single letter in one gene.
Read ArticleWhat the Science Actually Says About Gut Microbiome Testing—and What to Do Instead
Read ArticleWhat the CDC’s 2025 Birth Data Tells Us About Metabolic Health, Endocrine Disruption, and the Biology of Declining Fertility
Read ArticleThey were designed to lower blood sugar. Then they became weight loss drugs. Now the data suggests they’re doing something much bigger—targeting the machinery of aging itself.
Read ArticleAnd what it means for physicians who’ve been waiting on the sidelines
Read ArticleA breakthrough combination therapy just extended mouse lifespan dramatically—but only in males. Here’s why that sex difference might be the most important finding of all
Read ArticleWhy the longevity conversation needs to move from your blood work to your brain waves — and how a device called BrainTap is making meditation accessible to everyone.
Read ArticleCedars-Sinai study measures autophagic flux in humans for the first time during a fasting mimicking diet—bridging years of animal data with clinical reality
Read ArticleHow to stop and reverse insulin resistance
Read ArticleWhy the glucose tolerance test remains one of our best tools for diagnosing insulin resistance
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